Real-Time Monitoring in Biomanufacturing with Graphene Field-Effect Transistor Sensors: Detection of pH, Glucose, and Antibodies
December 2024
Ban, D., Hajian, R., Chan, M., Abdolrahimi, S., Barron, F., Datta, S., & Aran, K. (2024). Real-Time Monitoring in Biomanufacturing with Graphene Field-Effect Transistor Sensors: Detection of pH, Glucose, and Antibodies. Gen Biotechnology. https://doi.org/10.1089/genbio.2024.0043
Read moreApplications of Graphene Field Effect Biosensors for Biological Sensing
February 2024
Aran, K., Goldsmith, B., & Moarefian, M. (2024). Applications of Graphene Field Effect Biosensors for Biological Sensing. In Advances in Biochemical Engineering/Biotechnology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2024_252
Read moreCRISPR quality control on a chip
February 2024
Aran, K., Goldsmith, B.R. CRISPR quality control on a chip. Nat Rev Bioeng 2, 194–195 (2024). https://doi.org/10.1038/s44222-024-00159-4
Read moreDevelopment of Single Molecule Techniques for Sensing and Manipulation of CRISPR and Polymerase Enzymes
May 2023
Chu, J., Romero, A., Taulbee, J. and Aran, K. (2023), Development of Single Molecule Techniques for Sensing and Manipulation of CRISPR and Polymerase Enzymes. Small 2300328. https://doi.org/10.1002/smll.202300328
Read moreA Single Multiomics Transistor for Electronic Detection of SARS-Cov2 Variants Antigen and Viral RNA Without Amplification
April 2023
Ban, D.K., Hajian, R., Winton, A.J., Eom, R., Gupta, A., Kane, A.A., Liu, S., Sampath, R., Farrell, M.L., Coppock, M.B., Goldsmith, B. and Aran, K. (2023), A Single Multiomics Transistor for Electronic Detection of SARS-Cov2 Variants Antigen and Viral RNA Without Amplification. Adv. Mater. Technol. 2201945. https://doi.org/10.1002/admt.202201945.
Read moreEmerging Biosensing Technologies for the Diagnostics of Viral Infectious Diseases
March 2022
Gözde Kabay, Jonalyn DeCastro, Alara Altay, Katherine Smith, Hsiang-Wei Lu, Antonia McDonnell Capossela, Maryam Moarefian, Kiana Aran, and Can Dincer. "Emerging Biosensing Technologies for the Diagnostics of Viral Infectious Diseases." Advanced Materials (Wiley) 2022, 2201085. https://doi.org/10.1002/adma.202201085.
Read moreThe Promise of Graphene-Based Transistors for Democratizing Multiomics Studies
September 2021
H.-W. Lu, A. Kane, J. Parkinson, Y. Gao, R. Hajian, M. Heltzen, B. Goldsmith, and K. Aran. “The Promise of Graphene-Based Transistors for Democratizing Multiomics Studies.” Biosensors and Bioelectronics, September 8, 2021, 113605. https://doi.org/10.1016/j.bios.2021.113605.
Read moreErythrocytes, a New Contributor to Age-Associated Loss of Blood–Brain Barrier Integrity
August 2021
Amiri, P., DeCastro, J., Littig, J., Lu, H.-W., Liu, C., Conboy, I., Aran, K., Erythrocytes, a New Contributor to Age-Associated Loss of Blood–Brain Barrier Integrity. Adv. Sci. 2021, 2101912. https://doi.org/10.1002/advs.202101912
Read moreDiversification of the CRISPR Toolbox: Applications of CRISPR-Cas Systems Beyond Genome Editing
June 2021
S. Balderston, G. Clouse, J. Ripoll, G. Pratt, G. Gasiunas, J. Bock, E.P. Bennett, and K. Aran. Diversification of the CRISPR Toolbox: Applications of CRISPR-Cas Systems Beyond Genome Editing. The CRISPR Journal. Jun 2021.400-415.http://doi.org/10.1089/crispr.2020.0137
Read moreRapid and Electronic Identification and Quantification of Age‐Specific Circulating Exosomes via Biologically Activated Graphene Transistors
April 2021
Hajian, R., DeCastro, J., Parkinson, J., Kane, A., Camelo, A. F. R., Chou, P. P., Yang, J., Wong, N., Hernandez, E. D. O., Goldsmith, B., Conboy, I., Aran, K., Rapid and Electronic Identification and Quantification of Age‐Specific Circulating Exosomes via Biologically Activated Graphene Transistors. Adv. Biology 2021, 2000594. https://doi.org/10.1002/adbi.202000594
Read moreDiscrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor
April 2021
S. Balderston, J. Taulbee, E. Celaya, K. Fung, K. Smith, R. Hajian, G. Gasiunas, S. Kutanovas, R. Peytavi, F. Barron, B.R. Goldsmith, P. G. Collins, I. M. Conboy, V. Siksnys, K. Aran, Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor. Nature Biomedical Engineering, 2021, DOI 10.1038/s41551-021-00706-z
Read moreThe Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging
January 2021
J. DeCastro, J. Littig, P.P. Chou, J. Mack-Onyeike, A. Srinivasan, M.J. Conboy, I. M. Conboy, & K. Aran. The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging. Molecules (Basel, Switzerland), 26(3), 535 (2021).
Read moreProperties and Applications of Functionalized Graphene Oxide
October 2019
R. Hajian, K. Fung, P. Chou, S. Wang, S. Balderston, K. Aran, Graphene Oxide: Properties and Functionalization Methods. Material Matters, 2019, Vol. 14, Issue 1, 37-45
Read moreStructural determination of Enzyme-Graphene Nanocomposite Sensor Material
October 2019
D. K. Rai, M. Gurusaran, V. Urban, K. Aran, L. Ma, P. Li, S. Qian, T.N. Narayanan, P.M. Ajayan, D. Liepmann, K. Sekar, M.E. Álvarez-Cao, J.J. Escuder-Rodríguez, M.E Cerdán, M.I. González-Siso, S. Viswanathan, R. Paulmurugan, V. Renugopalakrishnan. Sci Rep 9, 15519 (2019) DOI:10.1038/s41598-019-51882-7
Read moreDetection of unamplified target genes via CRISPR–Cas9 immobilized on a graphene field-effect transistor.
March 2019
Reza Hajian, Sarah Balderston, Thanhtra Tran, Tara deBoer, Jessy Etienne, Mandeep Sandhu, Noreen A. Wauford, Jing-Yi Chung, Jolie Nokes, Mitre Athaiya, Jacobo Paredes, Regis Peytavi, Brett Goldsmith, Niren Murthy, Irina M. Conboy, Kiana Aran. (2019). Nature Biomedical Engineering doi: 10.1038/s41551-019-0371
Featured Cover Piece
Graphene-based biosensor for on-chip detection of Bio-orthogonally Labeled Proteins to Identify the Circulating Biomarkers of Aging during Heterochronic Parabiosis.
September 2018
Sadlowski, C. M., Balderston, S., Sandhu, M., Hajian, R., Liu, C., Tran, T. T., ... & Aran, K. (2018). Lab on a Chip. https://doi.org/10.1039/C8LC00446C
Read MoreAn Oral Microjet Vaccination System Elicits Antibody Production In Rabbits.
March 2017
Aran, K., Chooljian, M., Paredes, J., Rafi, M., Lee, K., Kim, A. Y., An, J., Yau, J. F., Chum, H., Conboy I., Murthy, N., Liepmann, D. (2017). An oral microjet vaccination system elicits antibody production in rabbits. Science Translational Medicine, 9(380). ttp://stm.sciencemag.org/content/9/380/eaaf6413.abstract
Read MoreIn Vivo Delivery Of Transcription Factors With Multifunctional Oligonucleotides
November 2015
Lee, K., Mohammad, R., Wang, X., Aran, K., Feng, X., Sterzo L., C., … Murthy, N. (n.d.). In vivo delivery of transcription factors with multifunctional oligonucleotides. Natural Materials, 14(7), 701–706. https://doi.org/10.1016/j.bbamem.2015.02.010.Cationic
Read MoreGraphene-protein Field Effect Biosensors: Glucose Sensing
November 2015
Viswanathan, S., Narayanan, T. N., Aran, K., Fink, K. D., Paredes, J., Ajayan, P. M., … Renugopalakrishanan, V. (2015). Graphene-protein field effect biosensors: Glucose sensing. Materials Today, 18(9), 513–522. https://doi.org/10.1016/j.mattod.2015.04.003
Read MoreStimuli-responsive Electrodes Detect Oxidative Stress And Liver Injury
December 2014
Aran, K., Parades, J., Rafi, M., Yau, J. F., Acharya, A. P., Zibinsky, M., Liepmann, D. and Murthy, N. (2015), Stimuli-Responsive Electrodes Detect Oxidative Stress and Liver Injury. Adv. Mater., 27: 1433–1436. doi:10.1002/adma.201404562
Featured Front Piece
A Turn-off Fluorescent Substrate For Horseradish Peroxidase Improves The Sensitivity Of Elisas
September 2014
Acharya, A.P., Sen, P., Aran, K., Gardner, A.B., Rafi, M., Dean, D., Murthy, N. Journal of Polymer Science Part A: Polymer Chemistry 53 (2), 206-210 doi:10.1002/pola.27376
Read MoreGraphene Protein Field Effect Biomedical Sensor for Glucose Measurements
March 2014
D. Liepmann, K. Aran, PM. Ajayan, S. Viswanathan, P. Li, V. Renugopalakrishnan, MRS Proceedings, 2014, DOI: 10.1557/opl.2015.302
Read moreAn Enzyme-free Digital Biosensor for Detection of Reactive Oxygen species
January 2014
K. Aran, J. Paredes, J. Yau. M. Rafi. MicroTAS 2014, Miniaturized Systems for Chemistry and Life Sciences.
Read moreContinuous Monitoring Of Inflammation Biomarkers During Simulated Cardiopulmonary Bypass Using A Microfluidic Immunoassay Device—a Pilot Study
January 2013
Sasso, L.A., Aran, K., Guan, Y., Ündar, AZahn, J.D. Artificial organs 37 (1) doi.org/10.1111/aor.12021
Read MoreMicrofiltration Platform For Continuous Blood Plasma Protein Extraction From Whole Blood During Cardiac Surgery
September 2011
Aran, K., Fok, A., Sasso, L. A., Kamdar, N., Guan, Y., Sun, Q., … Zahn, J. D. (2011). Microfiltration platform for continuous blood plasma protein extraction from whole blood during cardiac surgery. Lab on a Chip, 11(17), 2858–2868. http://doi.org/10.1039/c1lc20080a
Read MoreTranslational Research In Pediatric Extracorporeal Life Support Systems And Cardiopulmonary Bypass Procedures: 2011 Update
July 2011
Qiu, F., Talor, J., Zahn, J., Pauliks, L., Kunselman, A. R., Palanzo, D., … Ündar, A. (2011). Translational Research in Pediatric Extracorporeal Life Support Systems and Cardiopulmonary Bypass Procedures: 2011 Update. World Journal for Pediatric and Congenital Heart Surgery, 2(3), 476–481. doi.org/10.1177%2F2150135111402226
Read MoreDifferential Immune Activation During Simulated Cardiopulmonary Bypass Procedure Using Freshly Drawn And Week-old Blood—a Pilot Study
November 2010
Aran, K., Fok, A., Y, G., Sun, Q., Zahn, J., & Undar, A. (n.d.). Differential immune activation during simulated cardiopulmonary bypass procedure using freshly drawn and week-old blood—a pilot study. Artificial Organs, 34(11), 1048–53. https://www.ncbi.nlm.nih.gov/pubmed/21137157
Read MoreIrreversible, Direct Bonding Of Nanoporous Polymer Membranes To Pdms Or Glass Microdevices
January 2010
Aran, K., Sasso, L. A., Kamdar, N., & Zahn, J. D. (2010). Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices. Lab on a Chip, 10(5), 548. https://doi.org/10.1039/b924816a
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